Hemochron Signature+ Whole Blood Microcoagulation System

The Hemochron Signature+ is a simple, easy-to-use, portable microcoagulation system that can help you standardize point-of-care anticoagulation monitoring and maximize efficiency across your continuum of care.


  • Comprehensive point-of-care coagulation menu standardizes testing and improves efficiencies
  • Clot based cuvette technology measures fibrin clot formation providing confidence in results
  • Optimized ACT assays allows for monitoring of low and high level heparin applications
  • Accelerated ACT+ expedites endpoint, saving time-to result, and allowing patients to go on pump sooner

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Test menu

  • Activated Clotting Time (ACT+)
  • Activated Clotting Time-Low Range (ACT-LR) 
  • Prothrombin Time (PT)
  • Citrate Prothrombin Time (Citrated PT)
  • Activated Partial Thromboplastin Time (APTT)
  • Citrated  Partial Thromboplastin Time (Citrate APTT)


CLSI Formatted Procedures

ITC is pleased to provide CLSI Formatted Procedures solely for the convenience of our customers for downloading in an editable format. Use of such documents copied from this Website is for informational and non-commercial or personal use only. Any changes made to these procedures are the sole responsibility of the party making the changes and ITC accepts no liability for any consequence arising from the modification of materials or information copied from this site.
The files below may be opened as “Read Only”.  To customize/edit the file, please save the file on your local drive with a different file name.

Activated Clotting Time (ACT +)
Activated Partial Thromboplastin Time (APTT)
Citrate Activated Partial Thromboplastin Time (Citrate APTT)

Citrate Prothrombin Time (Citrate PT)

Low Range Activated Clotting Time (ACT-LR)

Prothrombin Time (PT)


  • Utilizes clot based technology
  • 12 week room temperature storage with 7 day open pouch stability
  • Low sample volume — only one drop required (15 µL)
  • Fresh, whole blood and citrated whole blood sample applications
  • Easy to fill sample well; with overflow reservoir
  • Self-contained waste channel reduces biohazards


Cuvette Intended Use Specimen
ACT-LR Monitors low to moderate heparin doses up to 2.5 units/mL of blood. Used in procedures such as cardiac catherization, Extracorporeal Membrane Oxygenation (ECMO), dialysis and Percutaneous Transluminal Coronary Angioplasty. Whole blood
ACT+ Monitors moderate to high levels of heparin (1-6 units/mL). Unaffected by aprotinin, hypothermia, and hemodilution. Whole blood
PT For performing a quantitative, one-stage prothrombin time. Venous or fingerstick samples
Citrate PT For performing a quantitative, one-stage prothrombin time. Citrated whole blood
APTT For performing a quantitative, one-stage APTT. For evaluation of low dose heparin anticoagulation (up to 1.5 units/mL of blood). Whole blood
Citrate APTT For performing a quantitative, one-stage APTT. For evaluation of low dose heparin anticoagulation (up to 1.5 units/mL of blood). Citrated whole blood



  • Configuration capabilities for added security
  • Operator and patient identification storage and tracking
  • Customizable notes feature
  • Internal EQC and temperature verification
  • Stores 400 patient and QC test results
  • LQC and EQC lockout
  • Connects to AegisPOC™, RALS®-Plus, PrecisionWeb®/SYBASE® and TELCOR QML®


directCheck Whole Blood Quality Control:
Easy to use, unitized liquid quality controls for Hemochron Signature Jr. Cuvettes


directCheck Control

ACT Cuvette (JACT+)  
     Level 1 Control DCJACT-N
     Level 2 Control DCJACT-A
ACT-LR Cuvette (JACT-LR)  
     Level 1 Control DCJLR-N
     Level 2 Control DCJLR-A
PT Cuvette (J201)  
     Level 1 Control DCJPT-N
     Level 2 Control DCJPT-A
Citrate PT Cuvette  (J201C)  
     Level 1 Control DCJCPT-N
     Level 2 Control DCJCPT-A
APTT Cuvette (J103)  
     Level 1 Control DCJAPTT-N
     Level 2 Control DCJAPTT-A
Citrate APTT Cuvette (J103C)  
     Level 1 Control DCJCPT-N
     Level 2 Control DCJCAPTT-A



Interface connectivity available through:

  • AegisPOC™
  • RALS®-Plus
  • PrecisionWeb®/SYBASE®